Research Field

• Nanotechnology/Materials, Molecular biochemistry, Living Organism Molecular Science
• Nanotechnology/Materials, Biochemistry

Research Keyword

• Chemical Biology
• Cell Biology
• Natural Product Chemistry
• Biologically active componds

Research theme

Books and other publications

• Advances in Food and Nutrition Research (Marine Medicinal Foods, Vol. 65: Implications and Applications: Animals and Microbes)
  Osamu Ohno; Kiyotake Suenaga; Daisuke Uemura, Joint work
  Elsevier, Mar. 2013
• Marine Pharmacognosy: Trends and Applications
  Toshiaki Teruya; Osamu Ohno; Kiyotake Suenaga, Contributor
  CRC Press, Oct. 2012

Paper

• Hedopeptolide, a NO Production Inhibitor from the Marine Cyanobacterium Okeania sp.
  Shunya Tojo; Noriyuki Natsume; Taiki Niino; Arihiro Iwasaki; Kiyotake Suenaga; Osamu Ohno; Toshiaki Teruya
  Journal of natural products, 27 Mar. 2025
• Eperisone Analogs, Rescuers of ＜i＞MiaB Defects As a Prokaryotic Homologue of ＜i＞CDKAL1, Suppress Blood Glucose Elevation in Rats
  Manabu Tejima; Tomoko Hashimoto; Osamu Ohno; Tomoyuki Hoshina; Kotaro Takasaki; Shintaro Taniguchi; Kanako Nakamura; Fan-Yan Wei; Kazuhito Tomizawa; Kenji Matsuno
  ACS Medicinal Chemistry Letters, 17 Jan. 2025

  URL
• Synthesis of Azahelicenes ＜i＞via Friedel‐Crafts‐Type Ring‐Closing Reaction of Axially Chiral Compounds
  Sonau Oikawa; Yuki Utsugi; Osamu Ohno; Eiko Yasui
  Asian Journal of Organic Chemistry, 14 Jun. 2024

  URL
• Suppression of Mast Cell Activation by GPR35: GPR35 Is a Primary Target of Disodium Cromoglycate
  Masumi Oka; Sohta Akaki; Osamu Ohno; Maho Terasaki; Yuho Hamaoka-Tamura; Michiko Saito; Shinichi Kato; Asuka Inoue; Junken Aoki; Kenji Matsuno; Kazuyuki Furuta; Satoshi Tanaka
  Journal of Pharmacology and Experimental Therapeutics, Jan. 2024, [Reviewed]
• Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group
  Yoshimasa Imanishi; Takuro Terasaki; Takuya Sano; Osamu Ohno; Eiko Yasui
  Chemical and Pharmaceutical Bulletin, 01 Apr. 2023, [Reviewed]
• Total Synthesis of Caldorazole, a Potent Mitochondrial Respiratory Chain Inhibitor without Chiral Centers
  Yuta Miyamoto; Arihiro Iwasaki; Haruka Fujimura; Chihiro Kudo; Naoaki Kurisawa; Osamu Ohno; Kiyotake Suenaga
  Journal of Organic Chemistry, 17 Feb. 2023, [Reviewed]
• Isolation of caldorazole, a thiazole-containing polyketide with selective cytotoxicity under glucose-restricted conditions
  Osamu Ohno; Arihiro Iwasaki; Kyouhei Same; Chihiro Kudo; Erika Aida; Kazuya Sugiura; Shimpei Sumimoto; Toshiaki Teruya; Etsu Tashiro; Siro Simizu; Kenji Matsuno; Masaya Imoto; Kiyotake Suenaga
  Organic Letters, 13 Jun. 2022, [Reviewed]
  Lead, Corresponding
• Inhibition of lipopolysaccharide-induced inflammatory signaling by soft coral-derived prostaglandin A2 in RAW264.7 cells
  Osamu Ohno; Eika Mizuno; Junichiro Miyamoto; Tomoyuki Hoshina; Takuya Sano; Kenji Matsuno
  Marine Drugs, 09 May 2022, [Reviewed]
  Lead, Corresponding
• Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2
  Hideaki Niwa; Chiduru Watanabe; Shin Sato; Toshiyuki Harada; Hisami Watanabe; Ryo Tabusa; Shunsuke Fukasawa; Ayane Shiobara; Tomoko Hashimoto; Osamu Ohno; Kana Nakamura; Keiko Tsuganezawa; Akiko Tanaka; Mikako Shirouzu; Teruki Honma; Kenji Matsuno; Takashi Umehara
  ACS Medicinal Chemistry Letters, 2022, [Reviewed]
• Anti-apoptotic activity of methyl (3R,4E,6Z,15E)-3-hydroxyoctadecatrienoate in human cervical carcinoma HeLa cells
  Osamu Ohno; Keigo Sato; Ryo Honma; Ruri Chiba; Kenji Matsuno
  Bioscience, Biotechnology, and Biochemistry, 2021, [Reviewed]
  Lead, Corresponding
• Discovery of Carbono(di)thioates as Indoleamine 2,3-Dioxygenase 1 Inhibitors
  Miyuki Kumazawa; Manabu Tejima; Miwa Fukuda; Shota Takeda; Kenji Suzuki; Yukiko Mizumoto; Kakeru Sato; Minoru Waki; Hiroyuki Miyachi; Akira Asai; Osamu Takikawa; Tomoko Hashimoto; Osamu Ohno; Kenji Matsuno
  ACS Medicinal Chemistry Letters, 2021, [Reviewed]
• Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction
  Osamu Ohno; Takuro Terasaki; Takuya Sano; Yuki Hitomi; Junichiro Miyamoto; Kenji Matsuno
  Bioorganic & Medicinal Chemistry Letters, 2020, [Reviewed]
  Lead, Corresponding
• PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells
  Ying Huang; Osamu Ohno; Kenji Miyamoto
  Bioscience, Biotechnology, and Biochemistry, 2019, [Reviewed]
• Phytotoxic property of Piper retrofractum fruit extracts and compounds against the germination and seedling growth of weeds
  Prapaipit Suwitchayanon; Osamu Ohno; Kiyotake Suenaga; Hisashi Kato‑Noguchi
  Acta Physiologiae Plantarum, 2019, [Reviewed]
• Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta
  Shimpei Sumimoto; Masayuki Kobayashi; Rio Sato; Seiichi Shinomiya; Arihiro Iwasaki; Shoichiro Suda; Toshiaki Teruya; Toshiyasu Inuzuka; Osamu Ohno; Kiyotake Suenaga
  Organic Letters, 2019, [Reviewed]
• Croissamide, a proline-rich cyclic peptide with an N-prenylated tryptophan from a marine cyanobacterium Symploca sp.
  Keitaro Iwasaki; Arihiro Iwasaki; Shimpei Sumimoto; Takuya Sano; Yuki Hitomi; Osamu Ohno; Kiyotake Suenaga
  Tetrahedron Letters, 2018, [Reviewed]
• Unified Total Synthesis, Stereostructural Elucidation, and Biological Evaluation of Sarcophytonolides
  Hiroyoshi Takamura; Takahiro Kikuchi; Kohei Iwamoto; Eiji Nakao; Naoki Harada; Taichi Otsu; Noriyuki Endo; Yuji Fukuda; Osamu Ohno; Kiyotake Suenaga; Yue-Wei Guo; Isao Kadota
  The Journal of Organic Chemistry, 2018, [Reviewed]
• Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity
  Miwa Fukuda; Tomomi Sasaki; Tomoko Hashimoto; Hiroyuki Miyachi; Minoru Waki; Akira Asai; Osamu Takikawa; Osamu Ohno; Kenji Matsuno
  Bioorganic & Medicinal Chemistry Letters, 2018, [Reviewed]
• Plant growth inhibitory activity and active substances with allelopathic potential of cogongrass (Imperata cylindrica) rhizome
  Masahiko Suzuki; Tohru Tominaga; Osamu Ohno; Arihiro Iwasaki; Kiyotake Suenaga; Hisashi Kato-Noguchi
  Weed Biology and Management, 2018, [Reviewed]
• N-Octanoyl tyramine, a phytotoxic compound in the roots of Cymbopogon nardus
  Prapaipit Suwitchayanon; Osamu Ohno; Kiyotake Suenaga; Hisashi Kato-Noguchi
  Acta Physiologiae Plantarum, 2017, [Reviewed]
• Involvement of allelopathy in inhibition of understory growth in red pine forests
  Hisashi Kato-Noguchi; Fukiko Kimura; Osamu Ohno; Kiyotake Suenaga
  Journal of Plant Physiology, 2017, [Reviewed]
• Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis
  Jin Cui; Maho Morita; Osamu Ohno; Tomoyuki Kimura; Toshiaki Teruya; Takumi Watanabe; Kiyotake Suenaga; Masakatsu Shibasaki
  Chemistry, 2017, [Reviewed]
• Apoptosis-inducing activity and antiproliferative effect of Paeoniflorigenone from moutan cortex
  Ying Huang; Osamu Ohno; Kiyotake Suenaga; Kenji Miyamoto
  Bioscience, Biotechnology, and Biochemistry, 2017, [Reviewed]
• Asparagus decline: Autotoxicity and autotoxic compounds in asparagus rhizomes
  Hisashi Kato-Noguchi; Keisuke Nakamura; Osamu Ohno; Kiyotake Suenaga; Nobuyuki Okuda
  Journal of Plant Physiology, 2017, [Reviewed]
• Anti-obesity activities of the yoshinone A and the related marine gamma-pyrone compounds
  Tomoyuki Koyama; Yoshinori Kawazoe; Arihiro Iwasaki; Osamu Ohno; Kiyotake Suenaga; Daisuke Uemura
  JOURNAL OF ANTIBIOTICS, Apr. 2016, [Reviewed]
• Total synthesis and stereochemical determination of yoshinone A
  Seiichi Shinomiya; Arihiro Iwasaki; Osamu Ohno; Kiyotake Suenaga
  Phytochemistry, 2016, [Reviewed]
• Kanamienamide, an Enamide with an Enol Ether from the Marine Cyanobacterium Moorea bouillonii
  Shimpei Sumimoto; Arihiro Iwasaki; Osamu Ohno; Kosuke Sueyoshi; Toshiaki Teruya; Kiyotake Suenaga
  Organic Letters, 2016, [Reviewed]
• Janadolide, a Cyclic Polyketide–Peptide Hybrid Possessing a tert-Butyl Group from an Okeania sp. Marine Cyanobacterium
  Hidetoshi Ogawa; Arihiro Iwasaki; Shinpei Sumimoto; Yuki Kanamori; Osamu Ohno; Masato Iwatsuki; Aki Ishiyama; Rei Hokari; Kazuhiko Otoguro; Satoshi O̅mura; Kiyotake Suenaga
  Journal of Natural Products, 2016, [Reviewed]
• A Potent Phytotoxic Substance in Aglaia odorata Lour.
  Hisashi Kato-Noguchi; Masahiko Suzuki; Kazutaka Noguchi; Osamu Ohno; Kiyotake Suenaga; Chamroon Laosinwattana
  Chemistry & Biodiversity, 2016, [Reviewed]
• Immunological Adjuvant Activity of Pectinioside A, the Steroidal Saponin from the Starfish Patiria pectinifera
  Osamu Kawase; Osamu Ohno; Kiyotake Suenaga; Xuenan Xuan
  Natural Product Communications, 2016, [Reviewed]
• Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes
  Shinichiro Okamoto; Arihiro Iwasaki; Osamu Ohno; Kiyotake Suenaga
  Journal of Natural Products, 2015, [Reviewed]
• Identification of a Molecular Target of Kurahyne, an Apoptosis-inducing Lipopeptide from Marine Cyanobacterial Assemblages
  Arihiro Iwasaki; Osamu Ohno; Shun Katsuyama; Maho Morita; Yukiko Sasazawa; Shingo Dan; Siro Simizu; Takao Yamori; Kiyotake Suenaga
  Bioorganic & Medicinal Chemistry Letters, 2015, [Reviewed]
• Structures and Biological Activities of Novel Biselyngbyaside Analogs Isolated from the Marine Cyanobacterium Lyngbya sp.
  Ayane Watanabe; Osamu Ohno; Maho Morita; Toshiyasu Inuzuka; Kiyotake Suenaga
  Bulletin of the Chemical Society of Japan, 2015, [Reviewed]
  Lead
• Isolation of monovalerianester A, an inhibitor of fat accumulation, from Valeriana fauriei
  Keiji Yuki; Mariko Ikeda; Shosuke Yoshida; Osamu Ohno; Kiyotake Suenaga; Kaoru Yamada; Daisuke Uemura; Kenji Miyamoto
  Natural Product Communications, 2015, [Reviewed]
• Isolation and Identification of an Allelopathic Substance from Hibiscus sabdariffa
  Prapaipit Suwitchayanon; Piyatida Pukclai; Osamu Ohno; Kiyotake Suenaga; Hisashi Kato-Noguchi
  Natural Product Communications, 2015, [Reviewed]
• A phytotoxic active substance in the decomposing litter of the fern Gleichenia japonica
  Hisashi Kato-Noguchi; Yoshihumi Saito; Osamu Ohno; Kiyotake Suenaga
  Journal of Plant Physiology, 2015, [Reviewed]
• Jahanyne, an Apoptosis-Inducing Lipopeptide from the Marine Cyanobacterium Lyngbya sp.
  Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Hidetoshi Ogawa; Kim Anh Nguyen; Kiyotake Suenaga
  Organic Letters, 2015, [Reviewed]
• Mebamamides A and B, Cyclic Lipopeptides Isolated from the Green Alga Derbesia marina
  Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Teruhiko Matsubara; Satoshi Shimada; Sato Toshinori; Kiyotake Suenaga
  Journal of Natural Products, 2015, [Reviewed]
• Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+ pumps with a unique mode of binding
  Maho Morita; Haruo Ogawa; Osamu Ohno; Takao Yamori; Kiyotake Suenaga; Chikashi Toyoshima
  FEBS Letters, 2015, [Reviewed]
• Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B
  Ichiro Hayakawa; Tomomi Nakamura; Osamu Ohno; Kiyotake Suenaga; Hideo Kigoshi
  ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, [Reviewed]
• An inhibitor of the adipogenic differentiation of 3T3-L1 cells, yoshinone A, and its analogs, isolated from the marine cyanobacterium Leptolyngbya sp.
  Toshiyasu Inuzuka; Keita Yamamoto; Arihiro Iwasaki; Osamu Ohno; Kiyotake Suenaga; Yoshinori Kawazoe; Daisuke Uemura
  Tetrahedron Letters, 2014, [Reviewed]
• Suaveolic acid: a potent phytotoxic substance of Hyptis suaveolens
  A. K. M. Mominul Islam; Osamu Ohno; Kiyotake Suenaga; Hisashi Kato-Noguchi
  The Scientific World Journal, 2014, [Reviewed]
• Maedamide, a novel chymotrypsin inhibitor from a marine cyanobacterial assemblage of Lyngbya sp.
  Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Shoichiro Suda; Kiyotake Suenaga
  Tetrahedron Letters, 2014, [Reviewed]
• Isolation and identification of a plant growth inhibitor from Tinospora tuberculata Beumee
  Hisashi Kato-Noguchi; Piyatida Pukclai; Osamu Ohno; Kiyotake Suenaga
  Acta Physiologiae Plantarum, 2014, [Reviewed]
• Growth limiting effects on various terrestrial plant species by an allelopathic substance, loliolide, from water hyacinth
  Hisashi Kato-Noguchi; Mayumi Moriyasu; Osamu Ohno; Kiyotake Suenaga
  Aquatic Botany, 2014, [Reviewed]
• Total Synthesis of Biselyngbyolide A
  Yurika Tanabe; Eisuke Sato; Naoya Nakajima; Akifumi Ohkubo; Osamu Ohno; Kiyotake Suenaga
  Organic Letters, 2014, [Reviewed]
• Phytotoxic Substances with Allelopathic Activity, Nimbolide B and Nimbic Acid B in Neem leaves
  Hisashi Kato-Noguchi; Md Salam; Osamu Ohno; Kiyotake Suenaga
  Molecules, 2014, [Reviewed]
• Two Novel Phytotoxic Substances from Leucas aspera
  A. K. M. Mominul Islam; Osamu Ohno; Kiyotake Suenaga; Hisashi Kato-Noguchi
  Journal of Plant Physiology, 2014, [Reviewed]
• Kurahamide, a Cyclic Depsipeptide Analog of Dolastatin 13 from a Marine Cyanobacterial Assemblage of Lyngbya sp.
  Arihiro Iwasaki; Shinpei Sumimoto; Osamu Ohno; Shoichiro Suda; Kiyotake Suenaga
  Bulletin of the Chemical Society of Japan, 2014, [Reviewed]
• Phytotoxic substances with allelopathic activity may be central to the strong invasive potential of Brachiaria brizantha
  Hisashi Kato-Noguchi; Ai Kobayashi; Osamu Ohno; Fukiko Kimura; Yoshiharu Fujii; Kiyotake Suenaga
  Journal of Plant Physiology, 2014, [Reviewed]
• Biselyngbyolide B, a Novel ER Stress-inducer Isolated from the Marine Cyanobacterium Lyngbya sp.
  Osamu Ohno; Ayane Watanabe; Maho Morita; Kiyotake Suenaga
  Chemistry Letters, 2014, [Reviewed]
  Lead
• Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.
  Arihiro Iwasaki; Osamu Ohno; Shinpei Sumimoto; Shoichiro Suda; Kiyotake Suenaga
  RSC Advances, 2014, [Reviewed]
• Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivatives
  Ohno Osamu; Morita Maho; Kitamura Kazuhiro; Teruya Toshiaki; Yoneda Kozo; Kita Masaki; Kigoshi Hideo; Suenaga Kiyotake
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 01 Mar. 2013, [Reviewed]
• A novel substance with allelopathic activity in Ginkgo biloba
  Hisashi Kato-Noguchi; Sayaka Takeshita; Fukiko Kimura; Osamu Ohno; Kiyotake Suenaga
  Journal of Plant Physiology, 2013, [Reviewed]
• Isolation and identification of an allelopathic substance from duckweed (Lemna minor L.)
  Tran T. N. Bich; Osamu Ohno; Kiyotake Suenaga; Hisashi Kato-Noguchi
  Allelopathy Journal, 2013, [Reviewed]
• Allelopathy is involved in the formation of pure colonies of the fern Gleichenia japonica
  Hisashi Kato-Noguchi; Yoshihumi Saito; Osamu Ohno; Kiyotake Suenaga
  Journal of Plant Physiology, 2013, [Reviewed]
• Total Synthesis, Structural Elucidation, and Structure–Cytotoxic Activity Relationship of (–)-Gummiferol
  Hiroyoshi Takamura; Hiroko Wada; Nan Lu; Osamu Ohno; Kiyotake Suenaga; Isao Kadota
  The Journal of Organic Chemistry, 2013, [Reviewed]
• Fluorescent aplyronine a: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells.
  Masaki Kita; Kozo Yoneda; Yuichiro Hirayama; Kota Yamagishi; Yuki Saito; Yuka Sugiyama; Yoshihiro Miwa; Osamu Ohno; Maho Morita; Kiyotake Suenaga; Hideo Kigoshi
  Chembiochem : a European journal of chemical biology, 13 Aug. 2012
• Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides
  Maho Morita; Osamu Ohno; Toshiaki Teruya; Takao Yamori; Toshiyasu Inuzuka; Kiyotake Suenaga
  Tetrahedron, 2012, [Reviewed]
• Isolation of allelopathic substance from Piper sarmentosum Roxb.
  Pukclai Piyatida; Kiyotake Suenaga; Osamu Ohno; Hisashi Kato-Noguchi
  Allelopathy Journal, 2012, [Reviewed]
• Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei
  Keiji Yuki; Mariko Ikeda; Kenji Miyamoto; Osamu Ohno; Kaoru Yamada; Daisuke Uemura
  Bioscience, Biotechnology, and Biochemistry, 2012, [Reviewed]
• Biselyngbyolide A, a Novel Cytotoxic Macrolide from the Marine Cyanobacterium Lyngbya sp.
  Maho Morita; Osamu Ohno; Kiyotake Suenaga
  Chemistry Letters, 2012, [Reviewed]
• Secondary Metabolites with New Medicinal Functions from Marine Organisms
  Ohno Osamu; Suenaga Kiyotake; Uemura Daisuke
  Advances in Food and Nutrition Research, 2012, [Reviewed]
• 4 Structures and Bioactivities of Novel Macrolides Leptolyngbyalides from Marine Cyanobacteria(Oral Presentation)
  Morita Maho; Ohno Osamu; Teruya Toshiaki; Kita Masaki; Kigoshi Hideo; Kitamura Kazuhiro; Hirata Kunio; Suenaga Kiyotake
  Symposium on the Chemistry of Natural Products, symposium papers, 02 Sep. 2011
• Halichonines A, B, and C, Novel Sesquiterpene Alkaloids from the Marine Sponge Halichondria okadai Kadota.
  Osamu Ohno; Tatsuhiko Chiba; Seiji Todoroki; Hideaki Yoshimura; Norihito Maru; Ken Maekawa; Hiroshi Imagawa; Kaoru Yamada; Atsushi Wakamiya; Kiyotake Suenaga; Daisuke Uemura
  Chemical Communications, 2011, [Reviewed]
  Lead
• Melanin Biosynthesis Inhibitors from Tarragon Artemisia dracunculus
  Masayoshi Yamada; Kazuhiko Nakamura; Taeko Watabe; Osamu Ohno; Masaru Kawagoshi; Norihito Maru; Nobuo Uotsu; Tomohiro Chiba; Kohji Yamaguchi; Daisuke Uemura
  Bioscience, Biotechnology, and Biochemistry, 2011, [Reviewed]
• Pinnarine, Another Member of the Halichlorine Family. Isolation and Preparation from Pinnaic Acid
  Shu Xu; Hideaki Yoshimura; Norihito Maru; Osamu Ohno; Hirokazu Arimoto; Daisuke Uemura
  Journal of Natural Products, 2011, [Reviewed]
• Lyngbyacyclamides A and B, novel cytotoxic peptides from marine cyanobacteria Lyngbya sp.
  Norihito Maru; Osamu Ohno; Daisuke Uemura
  TETRAHEDRON LETTERS, Dec. 2010, [Reviewed]
• SUNABEDINE, A NOVEL TOXIC BROMOTYROSINE-DERIVATIVE ALKALOID FROM OKINAWAN SPONGE, ORDER VERONGIDA
  Norihito Maru; Tomoyuki Koyama; Osamu Ohno; Kaoru Yamada; Daisuke Uemura
  HETEROCYCLES, Dec. 2010, [Reviewed]
• Bioorganic Study on the Neurotoxic Substances from Platypus (Ornithorhynchus anatinus), an Australian Unique Mammal
  Kita Masaki; Ohno Osamu; Yamada Kaoru; Kigoshi Hideo; Uemura Daisuke; Black David StC.
  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2010
• Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells
  Osamu Ohno; Taeko Watabe; Kazuhiko Nakamura; Masaru Kawagoshi; Nobuo Uotsu; Tomohiro Chiba; Masayoshi Yamada; Kohji Yamaguchi; Kaoru Yamada; Kenji Miyamoto; Daisuke Uemura
  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2010, [Reviewed]
• Symbiopolyol, a VCAM-1 Inhibitor from a Symbiotic Dinoflagellate of the Jellyfish Mastigias papna
  Novriyandi Hanif; Osamu Ohno; Makoto Kitamura; Kaoru Yamada; Daisuke Uemura
  JOURNAL OF NATURAL PRODUCTS, Jul. 2010, [Reviewed]
• Dinohydrazides A and B, Novel Hydrazides from a Symbiotic Marine Dinoflagellate
  Norihito Maru; Osamu Ohno; Kaoru Yamada; Daisuke Uemura
  CHEMISTRY LETTERS, Jun. 2010, [Reviewed]
• Papillamide, a Novel Fatty Acid Amide from the Red Alga Laurencia papillosa
  Norihito Maru; Osamu Ohno; Tomoyuki Koyama; Kaoru Yamada; Daisuke Uemura
  CHEMISTRY LETTERS, Apr. 2010, [Reviewed]
• Neocomplanines A and B, a Complanine Family Isolated from the Marine Fireworm
  Kazuhiko Nakamura; Yu Tachikawa; Osamu Ohno; Makoto Kitamura; Masami Suganuma; Daisuke Uemura
  JOURNAL OF NATURAL PRODUCTS, Mar. 2010, [Reviewed]
• Bioactive Secondary Metabolites from Symbiotic Marine Dinoflagellates: Symbiodinolide and Durinskiols
  Kita Masaki; Ohno Osamu; Han Chunguang; Uemura Daisuke
  CHEMICAL RECORD, 2010, [Reviewed]
• Duck-Billed Platypus Venom Peptides Induce Ca²⁺ Influx in Neuroblastoma Cells
  Kita, Masaki; Black, David StC; Ohno, Osamu; Yamada, Kaoru; Kigoshi, Hideo; Uemura, Daisuke
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2009, [Reviewed]
• Symbiospirols: Novel Long Carbon-Chain Compounds Isolated from Symbiotic Marine Dinoflagellate Symbiodinium sp.
  Yuta Tsunematsu; Osamu Ohno; Kaori Konishi; Kaoru Yamada; Masami Suganuma; Daisuke Uemura
  ORGANIC LETTERS, May 2009, [Reviewed]
• Application of FITC-labeled ternatin on its cellular localization in 3T3-L1 murine preadipocytes
  Kenichiro Shimokawa; Osamu Ohno; Kaoru Yamada; Yuichi Oba; Daisuke Uemura
  Chemistry Letters, 2009, [Reviewed]
• Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin, a potent fat-accumulation inhibitor against 3T3-L1 adipocytes
  Kenichiro Shimokawa; Kaoru Yamada; Osamu Ohno; Yuichi Oba; Daisuke Uemura
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jan. 2009, [Reviewed]
• 2 Isolation and structure determination of bioactive polyols using a novel degradation reaction(Oral Presentation)
  Han Chunguang; Hanif Novriyandi; Tsunematsu Yuta; Ohno Osamu; Yamano Yoshi; Kitamura Makoto; Yamada Kaoru; Kita Masaki; Suganuma Masami; Uemura Daisuke
  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2008
• 80(P-37) Structures of Cytotoxic Compounds from the Marine Organism Collected in Ehime Prefecture
  Kuramoto Makoto; Fujita Tohru; Ohno Osamu; Kawakami Megumi; Ono Noboru
  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2001

MISC

• 注目の論文－アクチンとチューブリンの複合体形成
  2014
  Lead, Last, Corresponding
• Apoptosis as a practical target for identifying anticancer agents of marine origin
  Osamu Ohno; Toshiaki Teruya; Kiyotake Suenaga; Daisuke Uemura
  Forum on Immunopathological Diseases and Therapeutics, 2013
  Lead
• GENETIC DIVERSITY OF FILAMENTOUS CYANOBACTERIA FROM SHORE REGIONS OF OKINAWA
  Shoichiro Suda; Rui Moriya; Shinpei Sumimoto; Osamu Ohno; Kiyotake Suenaga
  Journal of Marine Science and Technology, 2013
• STRUCTURE-ACTIVITY RELATIONSHIP OF OKADAIC ACID, A POTENT PROTEIN PHOSPHATASES PP1 AND PP2A INHIBITOR: 24-epi-OKADAIC ACID AND A 18-MEMBERED LACTONE ANALOG
  Masaki Kita; Makoto Kuramoto; Tatsuhiko Chiba; Akihiro Yamada; Nobuko Yamada; Takako Ishida; Takeharu Haino; Kaoru Yamada; Yasuharu Ijuin; Osamu Ohno; Daisuke Uemura
  HETEROCYCLES, Nov. 2008
• Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension
  Osamu Ohno; Mao Ye; Tomoyuki Koyama; Kazunaga Yazawa; Emi Mura; Hiroshi Matsumoto; Takao Ichino; Kaoru Yamada; Kazuhiko Nakamura; Tomohiro Ohno; Kohji Yamaguchi; Junji Ishida; Akiyoshi Fukamizu; Daisuke Uemura
  BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2008
• Durinskiol B: A new durinskiol congener from the symbiotic marine dinoflagellate Durinskia sp.
  Eric Richard Oktavianus Siwu; Osamu Ohno; Masaki Kita; Daisuke Uemura
  CHEMISTRY LETTERS, Mar. 2008
• Complanine, an inflammation-inducing substance isolated from the marine fireworm Eurythoe complanata
  Kazuhiko Nakamura; Yu Tachikawa; Makoto Kitamura; Osamu Ohno; Masami Suganuma; Daisuke Uemura
  ORGANIC & BIOMOLECULAR CHEMISTRY, 2008
• Inhibition of tumor angiogenesis by targeting endothelial surface ATP synthase with sangivamycin
  Yusuke Komi; Osamu Ohno; Yasuhiro Suzuki; Mariko Shimamura; Kentaro Shimokado; Kazuo Umezawa; Soichi Kojima
  JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Nov. 2007
• Inhibition of lipopolysaccharide activity by a bacterial cyclic lipopeptide surfactin
  T Takahashi; O Ohno; Y Ikeda; R Sawa; Y Homma; M Igarashi; K Umezawa
  JOURNAL OF ANTIBIOTICS, Jan. 2006
• Inhibition of lipopolysaccharide activity by an antifungal lipopeptide isolated from Bacillus subtilis.
  O Ohno; Y Suzuki; O Kawase; M Matsumoto; Y Homma; M Igarashi; K Umezawa
  FASEB JOURNAL, Mar. 2005
• Inhibition of cellular adhesion in human umbilical vein endothelial cells by NF-kappa B inhibitor DHMEQ under flow
  O Ohno; Y Shima; Y Ikeda; K Sakurai; K Watanabe; Y Kawai; K Umezawa
  ONCOLOGY RESEARCH, 2005
• Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-kappa B inhibitor
  Y Suzuki; C Sugiyama; O Ohno; K Umezawa
  TETRAHEDRON, Aug. 2004
• Isolation of heptadepsin, a novel bacterial cyclic depsipeptide that inhibits lipopolysaccharide activity
  O Ohno; Y Ikeda; R Sawa; M Igarashi; N Kinoshita; Y Suzuki; K Miyake; K Umezawa
  CHEMISTRY & BIOLOGY, Aug. 2004
• Inhibition of lipopolysaccharide activity by heptadepsin, a novel cyclic depsipeptide isolated from Paenibacillus sp.
  O Ohno; Y Suzuki; O Kawase; M Matsumoto; K Umezawa
  FASEB JOURNAL, May 2004
• Inhibition of adhesion molecule expression and cell adhesion by a novel NF-kappa B inhibitor DHMEQ
  K Umezawa; O Ohno; Y Shima; K Watanabe; Y Kawai
  FASEB JOURNAL, Mar. 2003
• Nondestructive evaluation of blood flow in a dialyzer using X-ray computed tomography
  Yoshitada Sakai; Shigehisa Wada; Hiroshi Matsumoto; Tomoko Suyama; Osamu Ohno; Izumi Anno
  Journal of Artificial Organs, 2003
• Selective growth inhibition by sangivamycin of human umbilical vein endothelial cells
  O Ohno; Y Shima; Y Ikeda; SI Kondo; K Kato; M Toi; K Umezawa
  INTERNATIONAL JOURNAL OF ONCOLOGY, May 2001
• Synthesis and anti-HIV activity of unusual nucleoside oxanosine derivatives.
  Y. Saito; C. Chaicharoenpong; O. Ohno; E. Ichikawa; S. Yamamura; K. Kato; M. Nakamura; T. Ohno; K. Umezawa
  Nucleic acids symposium series, 1999
• Synthesis and anti-HIV activity of unusual nucleoside oxanosine derivatives
  Y. Saito; C. Chaicharoenpong; O. Ohno; E. Ichikawa; S. Yamamura; K. Kato; M. Nakamura; T. Ohno; K. Umezawa
  Nucleic Acids Symposium Series, 1999

Lectures, oral presentations, etc.

• スズメバチに含まれるキチナーゼ阻害剤の単離、合成と機能解明
  31 Mar. 2024
• CDKAL1欠損による誤翻訳を解消するエペリゾン誘導体の合成と血糖値上昇抑制作用
  29 Mar. 2024
• 栄養飢餓選択的な細胞死誘導活性が期待されるpanaxcerol Bおよびエピマー体の合成研究
  18 Mar. 2024
• 核内受容体RORγt活性とkynurenine産生機構の相関の解析
  18 Mar. 2024
• センナリヅタ由来のkynurenine産生阻害剤caulerpinの単離および機能解析
  18 Mar. 2024
• CDKAL1 defectを解消するエペリゾン誘導体の合成と血糖値上昇抑制作用
  13 Nov. 2023
• センナリヅタ由来のkynurenine産生阻害剤caulerpinの単離と機能解析
  17 Oct. 2023
• Kynurenine産生機構における核内受容体RORγtの寄与
  17 Oct. 2023
• スズメバチに含まれるキチナーゼ阻害剤の単離、合成と機能解明
  14 Sep. 2023
• LSD1/LSD2阻害活性を有する2-phenylcyclopropylamine誘導体の合成研究
  28 Mar. 2023
• キヌレニン産生を抑制する環状デプシペプチドKNP-1の構造決定および全合成研究
  26 Mar. 2023
• スズメバチ由来新規キチナーゼ阻害剤の単離、合成と機能解明
  22 Mar. 2023
• 栄養飢餓選択的細胞死誘導物質panaxcerol Bの単離、合成と生物活性
  22 Mar. 2023
• 軟体サンゴ由来プロスタグランジンA2（PGA2）によるリポポリサッカライドのシグナル伝達阻害活性
  22 Mar. 2023
• スズメバチに含まれる新規生物活性物質の単離と機能解析
  14 Mar. 2023
• 海洋生物に由来する新規細胞応答制御物質の探索と機能解明
  22 Dec. 2022, [Invited]
• Kynurenine産生を抑制する環状デプシペプチドKNP-1の構造決定および全合成研究
  23 Nov. 2022
• Indoleamine 2,3-dioxygenase 1阻害活性を有するcarbono(di)thioate誘導体の発見
  23 Nov. 2022
• PARG阻害剤の合成および結合様式解明の検討
  23 Nov. 2022
• LSD2阻害剤の合成研究
  23 Nov. 2022
• 海洋シアノバクテリア由来新規キヌレニン産生阻害物質の単離と機能解明
  29 Oct. 2022
• 2-Alkylthio-oxazolineの加水分解開環体がIDO1阻害活性を示した
  17 Sep. 2022
• PARG阻害剤の合成および結合様式解明の検討
  17 Sep. 2022
• 2-Phenylcyclopropylamine（PCPA）誘導体の立体配置とlysine specific demethylase 1（LSD1）阻害活性の構造活性相関
  17 Sep. 2022
• オオスズメバチに含まれるキチナーゼ阻害剤の探索と機能解析
  17 Sep. 2022
• 海洋生物に由来する栄養飢餓選択的な細胞死誘導物質の単離と機能解析
  17 Sep. 2022
• がん細胞の代謝を標的とする天然由来新規化合物の単離と機能解明
  23 Apr. 2022, [Invited]
• 2-Phenylcyclopropylamine（PCPA）誘導体の立体配置とLSD1阻害活性の構造活性相関
  25 Mar. 2022
• 新規PARG阻害剤の構造活性相関および結合様式解明の検討
  25 Mar. 2022
• RORγt agonistによるキヌレニン産生阻害作用の解析
  25 Mar. 2022
• プロスタグランジンA2（PGA2）によるリポポリサッカライドのシグナル伝達阻害活性の解析
  23 Mar. 2022
• オオスズメバチ代謝物質に含まれる新規生物活性物質の探索と機能解析
  21 Mar. 2022
• 海洋シアノバクテリア由来新規キヌレニン産生阻害物質の単離と合成研究
  27 Nov. 2021, [Invited]
• キイロスズメバチ由来キチナーゼ阻害物質の単離と機能解析
  10 Sep. 2021
• キイロスズメバチ由来キチナーゼ阻害物質の単離と機能解析
  24 Mar. 2021
• 沖縄県産ソフトコーラルに由来するリポポリサッカライド機能阻害剤の単離
  22 Mar. 2021
• キヌレニン産生抑制剤の探索
  20 Mar. 2021
• ネクローシス様の細胞死を誘導する minnamide A の絶対立体配置の決定と生物活性
  24 Sep. 2020
• 海洋シアノバクテリア由来新規キヌレニン産生阻害剤の構造解析および生物活性
  23 Sep. 2020
• 海洋シアノバクテリア由来新規キヌレニン産生阻害剤の構造解析および生物活性
  23 Mar. 2020
• 海洋生物由来lipopolysaccharide機能阻害剤の探索研究
  23 Mar. 2020
• 海洋シアノバクテリア由来新規キヌレニン産生阻害剤の構造解析および生物活性
  28 Nov. 2019
• 海洋生物由来新規lipopolysaccharide機能阻害剤の探索
  28 Nov. 2019
• 海洋生物からの栄養飢餓選択的な細胞死誘導物質の探索
  28 Nov. 2019
• IDO阻害剤の合成研究：イソチオウレア構造の変換によるキヌレニン産生阻害剤の発見と作用機序解明
  28 Nov. 2019
• キヌレニン産生抑制剤の探索
  28 Nov. 2019
• LSD1/ LSD2阻害剤の合成研究
  28 Nov. 2019
• 種差を解消したGPR35アゴニストの合成
  28 Nov. 2019
• 海洋生物由来新規lipopolysaccharide機能阻害剤の探索
  14 Sep. 2019
• 沖縄県産ウミキノコからのlipopolysaccharide機能阻害物質の単離
  14 Sep. 2019
• シアノバクテリア由来新規キヌレニン産生阻害剤の構造解析
  14 Sep. 2019
• キヌレニン産生抑制剤の探索
  14 Sep. 2019
• 種差のない強活性GPR35アゴニストの合成研究
  14 Sep. 2019
• Synthtic studies on GPR35 agonist without species-specificity
  Koide; T.; Watanabe; T.; Naganuma; M. Hashimoto; T.; Akaki; S.; Furuta; K.; Yamamoto; Y.; Nagashima; S.; Tokiwa; H.; Tanaka; S.; Ohno; O.; Matsuno; K.
  27th International Society of Heterocyclic Chemistry Congress, 03 Sep. 2019
• Elucidation of the mechanism of action for benzimidazole analogues as potent kynurenine production inhibitor
  Fukuda; M.; Sasaki; T.; Hashimoto; T.; Miyachi; H.; Waki; M.;Asai; A.; Takikawa; O.; Ohno; O.; Matsuno; K.
  EFMC-ACSMEDI MedChem Frontiers 2019, 11 Jun. 2019
• 化合物ライブラリーからのキヌレニン産生抑制剤の探索
  07 Jun. 2019
• 海洋生物由来細胞応答制御物質の探索と機能解明
  07 Jun. 2019, [Invited]
• 2位にエステル基を有するクロモン誘導体のアルカリ加水分解における挙動
  18 May 2019
• LSD1阻害剤の合成研究
  23 Mar. 2019
• 種差の解消を指向したGPR35アゴニストの合成研究
  22 Mar. 2019
• 海洋生物由来小胞体ストレス誘導性アポトーシス阻害剤の探索
  18 Mar. 2019
• チアゾール含有ポリケチドtomurulineの合成研究
  17 Mar. 2019
• 海洋生物からの栄養飢餓選択的な細胞死誘導物質の探索
  17 Mar. 2019
• 種差の解消を指向したGPR35アゴニストの合成研究
  29 Nov. 2018
• Indileamine 2,3-dioxygenase阻害剤の合成および結合様式の解明
  29 Nov. 2018
• ポリADPリボース集積活性を有する抗がん剤候補MO2455の同定と構造活性相関
  29 Nov. 2018
• Isolation and Functional Analysis of Novel Compounds with Selective Cytotoxicity under Glucose-restricted Conditions
  Osamu Ohno; Yuki Nagaya; Ami Ito; Arihiro Iwasaki; Kiyotake Suenaga; Kenji Matsuno
  ICPAC Langkawi 2018,, 30 Oct. 2018, [Invited]
• 海洋生物由来細胞応答制御物質の探索と機能解析
  19 Oct. 2018, [Invited]
• がん免疫寛容解除を指向したindoleamine 2,3-dioxygenase阻害剤の合成
  15 Oct. 2018
• Computational analysis of potential compounds bound to GPR35 by using fragumentmolecular orbital calculations
  Yuta Yamamoto; Sota Nagashima; Sundaram Arulmozhiraja; Takuto Koide; Miyako Naganuma; Tomohiro Watanabe; Kazuyuki Furuta; Tomoko Hashimoto; Osamu Ohno; Satoshi Tanaka; Kenji Matsuno; Hiroaki Tokiwa
  09 Oct. 2018
• 海洋生物由来の小胞体ストレス誘導性細胞死阻害剤の探索
  02 Oct. 2018
• Indoleamine 2,3-dioxygenase阻害剤の合成および結合様式の解明
  02 Oct. 2018
• 海洋生物由来LPS誘導性NO産生阻害物質の探索
  02 Oct. 2018
• 種差の解消を指向したGPR35アゴニストの合成研究
  02 Oct. 2018
• 海洋生物由来新規キヌレニン産生抑制物質の探索
  12 Jul. 2018
• 海洋生物由来小胞体ストレス誘導性細胞死阻害剤の探索
  08 Jun. 2018
• 海洋生物由来リポポリサッカライド（LPS）機能調節物質の探索
  08 Jun. 2018
• 種差の解消を指向した GPR35アゴニストの合成研究
  26 Mar. 2018
• 海洋シアノバクテリア由来キヌレニン産生阻害剤 KNP-1 の同定および作用機序の解明
  26 Mar. 2018
• DHMEQ類縁体の合成とその活性評価
  25 Mar. 2018
• 海洋生物由来のリポポリサッカライド（LPS）の機能を阻害する化合物の探索
  22 Mar. 2018
• 海洋生物由来小胞体ストレス誘導性細胞死阻害剤の探索
  21 Mar. 2018
• 海洋生物からの栄養飢餓選択的な細胞死誘導物質の探索
  21 Mar. 2018
• Identification of kynurenine-production inhibitor from a marine cyanobacterium.
  Sasaki; T.; Ohno; O.; Asai; A.; Takikawa; O.; Matsuno; K.
  The 16th International Symposium on Advanced Technology, 02 Nov. 2017
• Synthetic studies on GPR35 agonist without specific difference.
  Watanabe; T.; Hashimoto; T.; Ohno; O.; Furuta; K.; Tanaka; S.; Matsuno; K.
  The 16th International Symposium on Advanced Technology, 02 Nov. 2017
• クロモン環を有するGPR35アゴニストの合成研究
  27 Oct. 2017
• 海洋シアノバクテリア由来キヌレニン産生阻害剤KNP-1の同定
  26 Oct. 2017
• 種差のないGPR35アゴニストの合成研究
  25 Oct. 2017
• 種差のないGPR35アゴニストの合成研究
  16 Sep. 2017
• 海洋生物からの栄養飢餓選択的な細胞死誘導物質の探索
  16 Sep. 2017
• 海洋生物からのキヌレニン産生抑制剤の探索
  16 Sep. 2017
• リポポリサッカライド（LPS）によるNO 産生を阻害する物質の探索
  16 Sep. 2017
• IDO阻害剤の合成研究
  16 Sep. 2017
• 小胞体ストレス誘導性細胞死を阻害する天然物の探索
  16 Sep. 2017
• Benzimidazole Analogues as Kynurenine Production Inhibitor by hopping from Indoleamine 2,3-Dioxygenase Inhibitior.
  Fukuda; M.; Sasaki; T.; Suzuki; K.; Miyachi; H.; Waki; M.; Asai; A.; Hashimoto; T.; Ohno; O.; Takikawa; O.; Matsuno; K.
  EFMC-ASMC'17 7th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, 28 Aug. 2017
• 海洋シアノバクテリア由来栄養飢餓選択的な細胞死誘導物質の単離と機能解析
  11 Jul. 2017
• 天然物に由来する細胞増殖抑制物質の探索、
  09 Jun. 2017
• 海洋生物由来キヌレニン産生抑制物質の探索
  佐々木智未、大野修、浅井章良、滝川修、松野研司
  新規素材探索研究会第16回セミナー, 09 Jun. 2017
• 海洋生物由来栄養飢餓選択的細胞死誘導物質の探索
  09 Jun. 2017
• 海洋生物由来キヌレニン産生抑制物質の探索
  佐々木智未、大野修、松野研司、浅井章良、滝川修
  日本化学会第97春季年会, 17 Mar. 2017
• 海洋生物由来のリポポリサッカライド（LPS）の機能を阻害する化合物の探索
  17 Mar. 2017
• kalkipyroneによる栄養飢餓選択的な細胞死誘導機構の解明
  17 Mar. 2017
• 海洋シアノバクテリア由来のリポペプチドの構造
  15 Sep. 2016
• 天然由来細胞応答制御物質の探索研究
  04 Jun. 2016
• 海洋生物由来ポリケチド化合物による栄養飢餓選択的な細胞死誘導機構の解析
  26 Mar. 2016
• Isolation of tomuruline, a novel thiazole containing polyketide with selective cytotoxicity under glucose-restricted conditions
  Osamu Ohno; Kyouhei Same; Chihiro Kudo; Shinpei Sumimoto; Toshiaki Teruya; Etsu Tashiro; Siro Simizu; Masaya Imoto; Kiyotake Suenaga
  Pacifichem 2015 conference, Hawaii, USA, 18 Dec. 2015
• Isolation and Functional Analysis of Novel Compounds with Selective Cytotoxicity under Glucose-restricted Conditions
  Osamu Ohno; Ami Ito; Shuntaro Obata; Arihiro Iwasaki; Kiyotake Suenaga; Kenji Matsuno
  The 14th International Symposium on Advanced Technology, Hachioji, 01 Nov. 2015
• 海洋シアノバクテリア由来新規細胞応答制御物質の単離と機能解析
  04 Aug. 2015
• 新規チアゾール含有ポリケチドtomurulineによる栄養飢餓選択的な細胞死誘導機構の解析
  11 Jun. 2015
• 海洋生物からの新物質探索研究―構造解明と機能解明の2種類の謎解きへの取り組み―
  25 Apr. 2015
• Isolation and functional analysis of a novel thiazole containing polyketide with selective cytotoxicity under nutrient starvation conditions,
  27 Mar. 2015
• 海洋シアノバクテリア由来細胞応答制御物質の探索研究
  10 May 2014
• 海洋生物由来新規二次代謝産物の探索と機能解析
  12 Oct. 2013
• 海洋産マクロリド，ビセリングビアサイド類の作用機構解析
  25 May 2013
• 海洋微細藻類由来新規チアゾール化合物tomurulineの構造と生物活性
  25 Mar. 2013
• 海洋シアノバクテリア由来新規マクロリドbiselyngbyaside類の構造と生物活性
  29 Jun. 2012
• クロイソカイメン由来新規セスキテルペンアルカロイドhalichonine類の構造と生物活性
  大野修、轟星児、吉村英明、丸範人、前川健、今川洋、若宮淳志、末永聖武、上村大輔
  日本化学会第92春季年会、横浜, 27 Mar. 2012
• 細胞応答を制御する新規生物活性天然物の探索研究
  08 Jul. 2011
• アクチン脱重合物質が有する腫瘍細胞へのアポトーシス誘導活性の解析
  10 Jun. 2011
• アクチン脱重合物質による腫瘍細胞へのアポトーシス誘導活性の解析
  24 May 2011
• Inhibitory effects of prenylated phenolic compounds isolated from Piper longum on melanin biosynthesis in B16 cells
  Osamu Ohno; Taeko Watabe; Kazuhiko Nakamura; Masaru Kawagoshi; Nobuo Uotsu; Tomohiro Chiba; Masayoshi Yamada; Kohji Yamaguchi; Kaoru Yamada; Daisuke Uemura
  Pacifichem 2010 conference, Hawaii, USA, 19 Dec. 2010
• クロイソカイメン由来新規アルカロイドhalichonine類の構造と生物活性
  29 Mar. 2010
• Inhibitory Effects of Benzyl Benzoate Derivatives against the Activity of Angiotensin II
  Osamu Ohno; Kazuhiko Nakamura; Taeko Watabe; Amelia Persson; Kaoru Yamada; Chie Fujiwara; Tomoyuki Koyama; Kazunaga Yazawa; Tomohiro Ohno; Kohji Yamaguchi; Daisuke Uemura
  The 50th Anniversary Meeting of the American Society of Pharmacognosy (ASP), Hawaii, USA, 28 Jun. 2009
• 植物由来クマリン系化合物によるアンジオテンシンII阻害作用
  29 Mar. 2009
• 微生物・植物を用いた新規素材探索研究
  05 Mar. 2009
• 海洋渦鞭毛藻由来の生物活性ポリオール類の単離および新分解反応を用いた構造決定法
  30 Sep. 2008
• 新生理活性物質の探索研究
  27 Jun. 2008
• Trial to access unknown natural products by using the genome of unculturable bacteria from marine sponges.
  The 4th joint IRTG Symposium between Nagoya University and University of Münster, Münster, Germany, 06 Sep. 2007
• 植物由来Angiotensin II受容体拮抗物質の探索
  Mar. 2007
• Isolation of Cyclic Lipopeptides Heptadepsin and Surfactin from Microorganisms as Inhibitors of Lipopolysaccharide Activity
  Osamu Ohno; Taichi Takahashi; Kazuo Umezawa
  ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan, Jul. 2006
• Inhibition of lipopolysaccharide activity by an antifungal lipopeptide isolated from Bacillus subtilis
  Osamu Ohno; Yoshikazu Suzuki; Osamu Kawase; Midori Matsumoto; Yoshiko Homma; Masayuki Igarashi; Kazuo Umezawa
  American Society for Biochemistry and Molecular Biology Annual Meeting 2005, San Diego, USA, Apr. 2005
• Inhibition of lipopolysaccharide activity by heptadepsin, a novel cyclic depsipeptide isolated from Paenibacillus sp.
  Osamu Ohno; Yoshikazu Suzuki; Osamu Kawase; Midori Matsumoto; Kazuo Umezawa
  American Society for Biochemistry and Molecular Biology Annual Meeting 2004, Boston, USA, Jun. 2004
• 放線菌由来異常ヌクレオシドによるヒト臍帯静脈内皮細胞の選択的増殖抑制
  Oct. 2000

Works

• 共生微細藻類の生産する長鎖ポリオール化合物の共生現象における役割の解明
  2008 - Present

Industrial Property Rights

• 特願2020-140431, 環状ペプチド化合物，キヌレニン産生阻害剤及び医薬組成物
• WO/2019/054386, PCT/JP2018/033694, 複素環化合物又はその塩，ＧＰＲ３５作動薬及び医薬組成物
• 特開2014-31353, 特願2012-180264, リングビアシクラミドを有効成分とする試薬、及び医薬
• 特開2012-102063, 特願2010-254171, メラニン産生抑制剤及び美白剤
• 特開2011-184401, 特願2010-053585, メラニン産生抑制剤及び美白剤
• 特開2006-193457, 特願2005-5722, エンドトキシン活性阻害剤
• WO2005-019245, PCT/JP2004/012076, ヘプタデプシン

Award

• Jun. 2011
• Mar. 2006
• Jun. 2004
  ASBMB Graduate/Postdoctoral Travel Award, The American Society for Biochemistry and Molecular Biology, Boston, USA

Research Themes

• Apr. 2024 - Mar. 2027
  天然由来機能性脂肪酸誘導体の応用と展開
• Apr. 2021 - Mar. 2024
  海洋生物由来新規キヌレニン産生阻害剤のがん免疫寛容抑制剤としての展開
• Apr. 2021 - Mar. 2024
  LSD阻害剤の創製：LSD1阻害剤の創薬展開およびLSD2機能解明の基盤構築
• Apr. 2018 - Mar. 2020
  Search for marine organisms-derived compounds that regulate the reprogramming mechanism of cancer cells
  Grant-in-Aid for Scientific Research (C), Kogakuin University
• Apr. 2015 - Mar. 2018
  Elucidation of the selective cytotoxicity of tomuruline, a novel thiazole-containing polyketide, under nutrient-starvation conditions
  Grant-in-Aid for Young Scientists (B), Kogakuin University
• Apr. 2013 - Mar. 2015
  The functional analyses of new macrolides isolated from marine cyanobacteria
  Grant-in-Aid for Young Scientists (B), Keio University
• Apr. 2008 - Mar. 2011
  Roles of long chain polyol compounds in symbiotic functions of microalgae
  Grant-in-Aid for Scientific Research (C), Nagoya University