
Kawahara Masahiro
| School of Advanced Engineering Department of Chemistry and Life Science | Professor |
Career
- Apr. 2025 - Present
School of Advanced Engineering, Kogakuin University, Department of Chemistry and Life Science, Professor - Apr. 2020 - Mar. 2025
National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Laboratory of Cell Vaccine, Project Leader - Jan. 2018 - Mar. 2020
Graduate School of Engineering, The University of Tokyo, Department of Bioengineering, Associate Professor - Apr. 2015 - Dec. 2017
Graduate School of Engineering, The University of Tokyo, Department of Chemistry and Biotechnology, Associate Professor - Aug. 2008 - Mar. 2015
Graduate School of Engineering, The University of Tokyo, Department of Chemistry and Biotechnology, Lecturer - Apr. 2007 - Aug. 2008
Graduate School of Engineering, The University of Tokyo, Department of Chemistry and Biotechnology, Assistant Professor - Apr. 2006 - Mar. 2008
University of Massachusetts Medical School, Department of Pathology, Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow for Research Abroad - Apr. 2002 - Mar. 2007
Graduate School of Engineering, The University of Tokyo, Department of Chemistry and Biotechnology, Research Associate - Apr. 2001 - Mar. 2002
Japan Society for the Promotion of Science (JSPS) Research Fellow (DC2)
Educational Background
- Mar. 2002
The University of Tokyo, Graduate School of Engineerng, Department of Chemistry and Biotechnology (Ph.D.) - Mar. 1999
The University of Tokyo, Graduate School of Engineerng, Department of Chemistry and Biotechnology (Master) - Mar. 1997
The University of Tokyo, School of Engineering, Department of Chemistry and Biotechnology (Bachelor)
Affiliated academic society
Books and other publications
- 治療用細胞の運命を制御するcfiCARの開発
Aug. 2025 - 人工受容体による治療細胞の機能化
Mar. 2025 - キメラ受容体の分子構築:バイオセンサーから細胞運命制御まで
Masahiro Kawahara
バイオ部会ニュースレター(化学工学会バイオ部会) 58, 17-22 (2023)., Dec. 2023 - キメラ受容体の研究継承者として
河原正浩
上田宏の思い出 生物化学工学研究フロントランナー (上田敏 編), シービーアール, 181-185 (2023)., Nov. 2023 - Interview 1:バイオ系のキャリアデザイン(就職支援OG・OBインタビュー編)
河原正浩
生物工学会誌 101(10), 556-557 (2023)., Oct. 2023 - 細胞創製時代のバイオ計測
Masahiro Kawahara
生物工学会誌 99(6), 291-294 (2021) doi: 10.34565/seibutsukogaku.99.6_291, Jun. 2021 - 治療・創薬を指向した機能性細胞創製技術の現状
Masahiro Kawahara
生物工学会誌 98(7), 406-407 (2020), Jul. 2020 - 細胞の生死を指標とした抗膜タンパク質抗体選択法の開発
Masahiro Kawahara
バイオ部会ニュースレター(化学工学会バイオ部会) 51, 3-9 (2020), Jul. 2020 - 人工受容体発現細胞でがん治療?!細胞創製時代の幕開け
KAWAHARA Masahiro
生物工学会誌 97(5), 279 (2019)., May 2019 - 細胞応答シグナルの自在な制御を可能にする受容体改変技術
Kawahara M
化学工学 82(5), 287 (2018)., May 2018 - Chemical reaction engineering methodologies for biomedical imaging analysis
Kawahara M
Biomedical Engineering Challenges: A Chemical Engineering Insight (Piemonte, V. et al., Ed.), Wiley, Chapter 7, 119-144 (2018). doi: 10.1002/9781119296034.ch7, 2018 - 2017 KSBB春季大会に参加して
Kawahara M
生物工学会誌 95(5), 303 (2017)., May 2017 - キメラ受容体による細胞運命制御系の構築とライブラリー選択への応用
Kawahara M
生物工学会誌 95(3), 127-135 (2017)., Mar. 2017 - 特集『産業応用を指向した細胞の操作・計測技術』特集によせて
Sakai S; Kawahara M
生物工学会誌 94(9), 530 (2016)., Sep. 2016 - 生物工学若手研究者の集い 夏のセミナー2016顛末記
Kawahara M
生物工学会誌 94(9), 582-583 (2016)., Sep. 2016 - 細胞内シグナル伝達を操る:再生医療・創薬への応用を目指して
Kawahara M
生物工学会誌 94(9), 535-538 (2016)., Sep. 2016 - 人獣共通感染症の機構解明と防除のための基盤技術の開発
Kawahara M
JATAFFジャーナル 4(7), 58 (2016)., Jul. 2016 - 造血幹細胞の増幅を指向したキメラ受容体の構築
Kawahara M; Nagamune T
『三次元ティッシュエンジニアリング最前線』, エヌ・ティー・エス社, pp. 95-101 (2015)., 2015 - 書評:生命システム工学 進化分子工学から進化生命工学へ
Kawahara M
バイオサイエンスとインダストリー 71(3), 297 (2013)., Mar. 2013 - 子育てと感染症
Kawahara M
バイオサイエンスとインダストリー 69(4), 314 (2011)., Apr. 2011 - 四半世紀後の化学工学
Kawahara M
化学工学 75(13) (創立75周年記念増刊号), 228 (2011)., 2011 - 生体における「危険信号」
Kawahara M
生物工学会誌 89(1), 28 (2011)., Jan. 2011 - The characteristic of chimeric receptors based on erythropoietin receptor
Liu W; Kawahara M; Ueda H; Nagamune T
Animal Cell Technology: Basic & Applied Aspects (Kamihira, M. et al., Ed.), 16, Springer, 265-270 (2010). doi: 10.1007/978-90-481-3892-0_43, 2010 - Growth control of mammalian cells via a human artificial chromosome harboring a chimeric receptor
Kawahara M; Inoue T; Ren X; Sogo T; Yamada H; Katoh M; Ueda H; Oshimura M; Nagamune T
Animal Cell Technology: Basic & Applied Aspects (Kamihira, M. et al., Ed.), 16, Springer, 253-258 (2010). DOI: 10.1007/978-90-481-3892-0_41, 2010 - 工学研究者が覗いた米国医学部の研究
Kawahara M
生物工学会誌 87(5), 258 (2009)., May 2009 - Selective expansion of genetically modified T cells using a chimeric IL-2 receptor for cancer therapy
Sogo T; Kawahara M; Ueda H; Nagamune T
Animal Cell Technology: Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, Springer, 11-18 (2009). doi: 10.1007/978-1-4020-9646-4_2, 2009 - Promoting non-hematopoietic cell proliferation by chimeric receptors
Tanaka K; Kawahara M; Ueda H; Nagamune T
Animal Cell Technology: Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, Springer, 87-93 (2009). doi: 10.1007/978-1-4020-9646-4_14, 2009 - Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency and analysis of the role of erythropoietin receptor domains in signal transduction
Liu W; Kawahara M; Ueda H; Nagamune T
Animal Cell Technology: Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, Springer, 187-193 (2009). doi: 10.1007/978-1-4020-9646-4_30, 2009 - 幹細胞工学による再生医療の進展
Kawahara M; Ueda H; Nagamune T
バイオ部会ニュースレター(化学工学会バイオ部会) 22, 5-7 (2009)., 2009 - マサチューセッツ大学留学体験記
Kawahara M
生命化学研究レター(日本化学会生命化学研究会)26, 42-45 (2008)., 2008 - 膜タンパク質の改変による細胞応答の制御
Kawahara M; Sogo T; Ueda H; Nagamune T
高分子 56(10), 828-830 (2007). doi: 10.1295/kobunshi.56.828, Oct. 2007 - 動物細胞での抗体選択・生産一貫システムの開発
Kawahara M; Ueda H; Nagamune T
抗体医薬の最前線 pp. 26-34,CMC出版(東京)(2007)., 2007 - 細胞表面受容体工学の最近の進歩
Ueda H; Kawahara M; Nagamune T
バイオサイエンスとインダストリー 64(2), 82–87 (2006)., Feb. 2006 - キメラ受容体を用いた抗体産生細胞の安価な増殖促進
Kawahara M; Ueda H; Nagamune T
バイオインダストリー 21(11), 63-68 (2004)., Nov. 2004 - 抗体-受容体キメラによる遺伝子導入細胞のポジティブ選択法
Kawahara M; Ueda H; Nagamune T
実験医学 22(6), 871–875 (2004)., Jun. 2004 - 抗体を用いた受容体のエンジニアリング−効果的な細胞医療を目指して−
Kawahara M; Ueda H; Nagamune T
抗体エンジニアリングの最前線. 植田充美監修, シーエムシー出版(東京), 37-47 (2004)., 2004 - Cell proliferation switch responsive to fluorescein dimer
Kimura H; Kawahara M; Tomlinson IM; Ueda H; Nagamune T
Animal Cell Technology: Basic & Applied Aspects (Yagasaki, K., Ed.), 13, Kluwer Academic Publishers, Dordrecht, 335-339 (2004). doi: 10.1007/978-94-017-0726-8_58, 2004 - Antigen-mediated genetically modified cell amplification
Kawahara M; Ueda H; Tsumoto K; Kumagai I; Mahoney W; Nagamune T
ACS SYMPOSIUM SERIES 830 (Biological System Engineering), 140-152 (2002). doi: 10.1021/bk-2002-0830.ch011, 2002 - Lysozyme-dependent proliferation switch: hematopoietic and hybridoma cell growth control with the use of antibody/gp130 chimera
Kawahara M; Natsume A; Terada S; Kato K; Tsumoto K; Kumagai I; Miki M; Mahoney W; Ueda H; Nagamune T
Animal cell technology for creation of new era (JAACT 2000), Kluwer Academic Publishers, Dordrecht, 337-341 (2002). doi: 10.1007/978-94-017-0728-2_60, 2002 - 無血清・低血清培地で増殖する動物細胞の創出
Kawahara M; Ueda H; Nagamune T
バイオサイエンスとインダストリー 59(9), 35–36 (2001)., Sep. 2001 - 抗原に応答する抗体−サイトカインキメラレセプター
Nagamune T; Ueda H; Kawahara M; Aburatani T
バイオミメティックスハンドブック(Osada, Y., Ed.), NTS, Tokyo, 332-337 (2000)., 2000 - 細胞表層工学を用いた動物細胞の育種
Nagamune T; Kawahara M; Aburatani T; Ueda H
生物工学会誌 77(12), 510–513 (1999)., Dec. 1999 - Monovalent antigen activates antibody/cytokine receptor chimera and controls hematopoietic cell growth
Kawahara M; Ueda H; Tsumoto K; Todokoro K; Mahoney W; Kumagai I; Nagamune T
Animal Cell Technology: Challenges for the 21st Century(JAACT/ESACT) (Sasaki, R., Ed.), Kluwer Academic Publishers, Dordrecht, 255-259 (1999). doi: 10.1007/0-306-46869-7_45, 1999
Paper
- Refining minimal engineered receptors for specific activation of on-target signaling molecules.
Masashi Miura; Masahiro Kawahara
Scientific reports, 30 Dec. 2024 - Synthetic receptor scaffolds significantly affect the efficiency of cell fate signals.
Kirato Umene; Masahiro Kawahara
Scientific reports, 09 Mar. 2024 - Phenotypic screening of signaling motifs that efficiently induce cell proliferation.
Kirato Umene; Teruyuki Nagamune; Masahiro Kawahara
Scientific reports, 20 Sep. 2023 - Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells.
Takahiro Sogo; Shu Nakao; Tasuku Tsukamoto; Tomoe Ueyama; Yukihiro Harada; Dai Ihara; Tomoaki Ishida; Masato Nakahara; Koji Hasegawa; Yuka Akagi; Yasuyuki S Kida; Osamu Nakagawa; Teruyuki Nagamune; Masahiro Kawahara; Teruhisa Kawamura
Inflammation and regeneration, 10 Feb. 2023 - Constitutively active GPR43 is crucial for proper leukocyte differentiation.
Sosuke Miyasato; Kurumi Iwata; Reika Mura; Shou Nakamura; Keisuke Yanagida; Hideo Shindou; Yosuke Nagata; Masahiro Kawahara; Satoshi Yamaguchi; Junken Aoki; Asuka Inoue; Teruyuki Nagamune; Takao Shimizu; Motonao Nakamura
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan. 2023 - Sequential control of myeloid cell proliferation and differentiation by cytokine receptor-based chimeric antigen receptors.
Kyoko Nakajima; Zhongchuzi Shen; Masashi Miura; Hideto Nakabayashi; Masahiro Kawahara
PloS one, 27 Dec. 2022 - A growth-based platform for detecting domain-peptide interactions in the cytoplasm of mammalian cells.
Yosuke Kimura; Daiki Kashima; Masahiro Kawahara
Scientific reports, 27 Oct. 2022 - Cell fate-inducing CARs orthogonally control multiple signaling pathways.
Kyoko Nakajima; Hideto Nakabayashi; Masahiro Kawahara
Biotechnology journal, May 2022 - Thrombopoietin receptor-based protein-protein interaction screening (THROPPIS).
Makiko Horikawa; Yosuke Kakiuchi; Daiki Kashima; Kenichiro Ogawa; Masahiro Kawahara
Biotechnology and bioengineering, Jan. 2022 - Rational design of heterodimeric receptors capable of activating target signaling molecules.
Tatphon Kongkrongtong; Ruolan Zhang; Masahiro Kawahara
Scientific reports, 19 Aug. 2021 - Production of an active Mus musculus IL-3 using updated silkworm-based baculovirus expression vector system
Ryo Nagai; Takeru Ebihara; Kohei Kakino; Akitsu Masuda; Jian Xu; Kosuke Minamihata; Noriho Kamiya; Tatphon Kongkrongtong; Masahiro Kawahara; Hiroaki Mon; Tsuguru Fujii; Takahiro Kusakabe; Jae Man Lee
Journal of Asia-Pacific Entomology, Aug. 2021 - Reprogramming signal transduction through a designer receptor tyrosine kinase.
Tatphon Kongkrongtong; Yuka Sumigama; Teruyuki Nagamune; Masahiro Kawahara
Communications biology, 17 Jun. 2021 - Tailoring minimal synthetic receptors to reconstitute signaling properties through multiple tyrosine motifs.
Kyoko Nakajima; Shota Araki; Masahiro Kawahara
Biochemical and biophysical research communications, 11 Jun. 2021 - Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers.
Daiki Kashima; Masahiro Kawahara
Scientific reports, 03 Jun. 2021 - A Novel Cell-Based Intracellular Protein-Protein Interaction Detection Platform (SOLIS) for Multimodality Screening.
Daiki Kashima; Miho Kageoka; Yosuke Kimura; Makiko Horikawa; Masashi Miura; Makoto Nakakido; Kouhei Tsumoto; Teruyuki Nagamune; Masahiro Kawahara
ACS synthetic biology, 21 May 2021 - Using Engineered Mammalian Cells for an Epitope-Directed Antibody Affinity Maturation System.
Akihiro Eguchi; Masahiro Kawahara
Methods in molecular biology (Clifton, N.J.), 2021 - Chimeric G-CSF Receptor-Mediated STAT3 Activation Contributes to Efficient Induction of Cardiomyocytes from Mouse Induced Pluripotent Stem Cells.
Tasuku Tsukamoto; Takahiro Sogo; Tomoe Ueyama; Shu Nakao; Yukihiro Harada; Dai Ihara; Yuka Akagi; Yasuyuki S Kida; Koji Hasegawa; Teruyuki Nagamune; Masahiro Kawahara; Teruhisa Kawamura
Biotechnology journal, Feb. 2020, [Reviewed] - An epitope-directed antibody affinity maturation system utilizing mammalian cell survival as readout.
Akihiro Eguchi; Makoto Nakakido; Satoru Nagatoishi; Daisuke Kuroda; Kouhei Tsumoto; Teruyuki Nagamune; Masahiro Kawahara
Biotechnology and bioengineering, Jul. 2019, [Reviewed] - A Suicide Switch Directly Eliminates Intracellular scFv Oligomers in the Cytoplasm of Mammalian Cells.
Nguyen TD; Nagamune T; Kawahara M
Biotechnology journal, Jan. 2019, [Reviewed] - Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.
Ishizuka S; Lai CY; Otsu M; Nakauchi H; Nagamune T; Kawahara M
ACS synthetic biology, Jul. 2018, [Reviewed] - Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors
Saka K; Lai CY; Nojima M; Kawahara M; Otsu M; Nakauchi H; Nagamune T
Stem Cell Reviews and Reports, Feb. 2018, [Reviewed] - Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors
Koichiro Saka; Chen-Yi Lai; Masanori Nojima; Masahiro Kawahara; Makoto Otsu; Hiromitsu Nakauchi; Teruyuki Nagamune
Stem Cell Reviews and Reports, 01 Feb. 2018, [Reviewed] - Cell-Surface Expression Levels Are Important for Fine-Tuning the Performance of Receptor Tyrosine Kinase-Based Signalobodies
Hideto Nakabayashi; Masahiro Kawahara; Teruyuki Nagamune
BIOTECHNOLOGY JOURNAL, Dec. 2017, [Reviewed] - Microfluidic preparation of anchored cell membrane sheets for in vitro analyses and manipulation of the cytoplasmic face
Shin Izuta; Satoshi Yamaguchi; Ryuji Misawa; Shinya Yamahira; Modong Tan; Masahiro Kawahara; Tomoko Suzuki; Tomoko Takagi; Kae Sato; Motonao Nakamura; Teruyuki Nagamune; Akimitsu Okamoto
SCIENTIFIC REPORTS, Nov. 2017, [Reviewed] - Engineering a growth sensor to select intracellular antibodies in the cytosol of mammalian cells
Thuy Duong Nguyen; Hitoshi Takasuka; Yoshihiro Kaku; Satoshi Inoue; Teruyuki Nagamune; Masahiro Kawahara
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Jul. 2017, [Reviewed] - A Chemically Inducible Helper Module for Detecting Protein-Protein Interactions with Tunable Sensitivity Based on KIPPIS
Daiki Kashima; Raiji Kawade; Teruyuki Nagamune; Masahiro Kawahara
ANALYTICAL CHEMISTRY, May 2017, [Reviewed] - Differentiation signalobody: Demonstration of antigen-dependent osteoclast differentiation from a progenitor cell line
Hideto Nakabayashi; Saeko Aoyama; Masahiro Kawahara; Teruyuki Nagamune
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Sep. 2016, [Reviewed] - Ligand-inducible dimeric antibody for selecting antibodies against a membrane protein based on mammalian cell proliferation
Tomohiro Miura; Teruyuki Nagamune; Masahiro Kawahara
BIOTECHNOLOGY AND BIOENGINEERING, May 2016, [Reviewed] - Growth signalobody selects functional intrabodies in the mammalian cytoplasm
Songhee Lee; Yoshihiro Kaku; Satoshi Inoue; Teruyuki Nagamune; Masahiro Kawahara
BIOTECHNOLOGY JOURNAL, Apr. 2016, [Reviewed] - Selection of cDNA candidates that induce oligomerization of NLRP3 using a chimeric receptor approach
Shingo Honda; Teruyuki Nagamune; Masahiro Kawahara
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Aug. 2015, [Reviewed] - Domain structure of growth signalobodies critically affects the outcome of antibody library selection
Rie Yoshida; Masahiro Kawahara; Teruyuki Nagamune
JOURNAL OF BIOCHEMISTRY, Jun. 2015, [Reviewed] - Collagen Surfaces Modified with Photo-Cleavable Polyethylene Glycol-Lipid Support Versatile Single-Cell Arrays of Both Non-adherent and Adherent Cells
Shinya Yamahira; Satoshi Yamaguchi; Masahiro Kawahara; Teruyuki Nagamune
MACROMOLECULAR BIOSCIENCE, Dec. 2014, [Reviewed] - Split focal adhesion kinase for probing protein-protein interactions
Yidan Ma; Teruyuki Nagamune; Masahiro Kawahara
BIOCHEMICAL ENGINEERING JOURNAL, Sep. 2014, [Reviewed] - AAG8 promotes carcinogenesis by activating STAT3
Bing Sun; Masahiro Kawahara; Shogo Ehata; Teruyuki Nagamune
CELLULAR SIGNALLING, Sep. 2014, [Reviewed] - Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells
Satoru Mabe; Teruyuki Nagamune; Masahiro Kawahara
SCIENTIFIC REPORTS, Aug. 2014, [Reviewed] - S-Fms signalobody enhances myeloid cell growth and migration
Masahiro Kawahara; Azusa Hitomi; Teruyuki Nagamune
BIOTECHNOLOGY JOURNAL, Jul. 2014, [Reviewed] - A Novel Platform For Antibody Library Selection in Mammalian Cells Based on a Growth Signalobody
Rie Yoshida; Masahiro Kawahara; Teruyuki Nagamune
BIOTECHNOLOGY AND BIOENGINEERING, Jun. 2014, [Reviewed] - Modeling tandem AAG8-MEK inhibition in melanoma cells
Bing Sun; Masahiro Kawahara; Teruyuki Nagamune
CANCER MEDICINE, Jun. 2014, [Reviewed] - Quantitative Control of Intracellular Signaling Activity Through Chimeric Receptors Incorporating Multiple Identical Tyrosine Motifs
Koichiro Saka; Masahiro Kawahara; Teruyuki Nagamune
BIOTECHNOLOGY AND BIOENGINEERING, May 2014, [Reviewed] - Antigen-responsive regulation of Cell motility and migration via the signalobodies based on c-Fms and c-Mpl
Masahiro Kawahara; Azusa Hitomi; Teruyuki Nagamune
BIOTECHNOLOGY PROGRESS, Mar. 2014, [Reviewed] - Construction of antibody/insulin receptor chimera for growth induction of mammalian cells
Hideto Nakabayashi; Masahiro Kawahara; Kento Tanaka; Teruyuki Nagamune
Cytotechnology, Dec. 2013, [Reviewed] - Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells
Koichiro Saka; Masahiro Kawahara; Jinying Teng; Makoto Otsu; Hiromitsu Nakauchi; Teruyuki Nagamune
JOURNAL OF BIOTECHNOLOGY, Dec. 2013, [Reviewed] - Reconstitution of a cytokine receptor scaffold utilizing multiple different tyrosine motifs
Koichiro Saka; Masahiro Kawahara; Teruyuki Nagamune
Biotechnology and Bioengineering, Dec. 2013, [Reviewed] - Cell Fate Conversion by Conditionally Switching the Signal-Transducing Domain of Signalobodies
Yuichiro Tone; Masahiro Kawahara; Jun Hayashi; Teruyuki Nagamune
BIOTECHNOLOGY AND BIOENGINEERING, Dec. 2013, [Reviewed] - Construction of Unnatural Heterodimeric Receptors Based on IL-2 and IL-6 Receptor Subunits
Kenichiro Ogawa; Masahiro Kawahara; Teruyuki Nagamune
BIOTECHNOLOGY PROGRESS, Nov. 2013, [Reviewed] - Death Signalobody: Inducing Conditional Cell Death in Response to a Specific Antigen
Yuichiro Tone; Masahiro Kawahara; Daichi Kawaguchi; Hiroshi Ueda; Teruyuki Nagamune
HUMAN GENE THERAPY METHODS, Jun. 2013, [Reviewed] - Analysis of cellular phenotype during in vitro immunization of murine splenocytes for generating antigen-specific immunoglobulin
Takashi Inagaki; Tatsunari Yoshimi; Satoshi Kobayashi; Masahiro Kawahara; Teruyuki Nagamune
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Mar. 2013, [Reviewed] - Engineering of mammalian cell membrane proteins
Masahiro Kawahara; Teruyuki Nagamune
CURRENT OPINION IN CHEMICAL ENGINEERING, Nov. 2012, [Reviewed] - Activation of target signal transducers utilizing chimeric receptors with signaling-molecule binding motifs
Koichiro Saka; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
BIOTECHNOLOGY AND BIOENGINEERING, Jun. 2012, [Reviewed] - Growth control of genetically modified cells using an antibody/c-Kit chimera
Etsuji Kaneko; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, May 2012, [Reviewed] - Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera
Masahiro Kawahara; Jianhong Chen; Takahiro Sogo; Jinying Teng; Makoto Otsu; Masafumi Onodera; Hiromitsu Nakauchi; Hiroshi Ueda; Teruyuki Nagamune
CYTOKINE, Sep. 2011, [Reviewed] - Engineering cytokine receptors to control cellular functions
Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
BIOCHEMICAL ENGINEERING JOURNAL, Feb. 2010, [Reviewed] - A rapid antibody isolation system (RAntIS) based on in vitro immunization
Inagaki T; Kawahara M; Nagamune T
European Cells and Materials, 2010, [Reviewed] - The Characteristic of Chimeric Receptors Based on Erythropoietin Receptor
Wenhai Liu; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
ANIMAL CELL TECHNOLOGY: BASICS & APPLIED ASPECTS, 2010, [Reviewed] - Growth Control of Mammalian Cells via a Human Artificial Chromosome Harboring a Chimeric Receptor
Masahiro Kawahara; Toshiaki Inoue; Xianying Ren; Takahiro Sogo; Hidetoshi Yamada; Motonobu Katoh; Hiroshi Ueda; Mitsuo Oshimura; Teruyuki Nagamune
ANIMAL CELL TECHNOLOGY: BASICS & APPLIED ASPECTS, 2010, [Reviewed] - Analysis of the Role of Tripeptidyl Peptidase II in MHC Class I Antigen Presentation In Vivo
Masahiro Kawahara; Ian A. York; Arron Hearn; Diego Farfan; Kenneth L. Rock
JOURNAL OF IMMUNOLOGY, Nov. 2009, [Reviewed] - Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera
Masahiro Kawahara; Yusuke Shimo; Azusa Hitomi; Yuki Mochida; Takahiro Sogo; Hiroshi Ueda; Teruyuki Nagamune
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Nov. 2009, [Reviewed] - Construction of rapid antibody isolation system and development of the novel biomarker using RAntIS
Takashi Inagaki; Masahiro Kawahara; Teruyuki Nagamune
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Nov. 2009, [Reviewed] - Selection and Growth Regulation of Genetically Modified Cells with Hapten-Specific Antibody/Receptor Tyrosine Kinase Chimera
Kento Tanaka; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
BIOTECHNOLOGY PROGRESS, Jul. 2009, [Reviewed] - The Influence of Domain Structures on the Signal Transduction of Chimeric Receptors Derived from the Erythropoietin Receptor
Wenhai Liu; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
JOURNAL OF BIOCHEMISTRY, May 2009, [Reviewed] - T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera
Takahiro Sogo; Masahiro Kawahara; Hiroshi Ueda; Makoto Otsu; Masafumi Onodera; Hiromitsu Nakauchi; Teruyuki Nagamune
CYTOKINE, Apr. 2009, [Reviewed] - Selective Expansion of Genetically Modified T Cells Using a Chimeric IL-2 Receptor for Cancer Therapy
Takahiro Sogo; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
ANIMAL CELL TECHNOLOGY: BASIC AND APPLIED ASPECTS, VOL 15, 2009, [Reviewed] - Promoting Non-Hematopoietic Cell Proliferation by Chimeric Receptors
Kento Tanaka; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
ANIMAL CELL TECHNOLOGY: BASIC AND APPLIED ASPECTS, VOL 15, 2009, [Reviewed] - Construction of a Fluorescein-Responsive Chimeric Receptor with Strict Ligand Dependency and Analysis of the Role of Erythropoietin Receptor Domains in Signal Transduction
Wenhai Liu; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
ANIMAL CELL TECHNOLOGY: BASIC AND APPLIED ASPECTS, VOL 15, 2009, [Reviewed] - Construction of a Fluorescein-Responsive Chimeric Receptor With Strict Ligand Dependency
Wenhai Liu; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune
BIOTECHNOLOGY AND BIOENGINEERING, Dec. 2008, [Reviewed] - Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera
Takahiro Sogo; Masahiro Kawahara; Kouhei Tsumoto; Izumi Kumagai; Hiroshi Ueda; Teruyuki Nagamune
JOURNAL OF IMMUNOLOGICAL METHODS, Aug. 2008, [Reviewed] - Antigen-mediated migration of murine pro-B Ba/F3 cells via an antibody/receptor chimera
Masahiro Kawahara; Yusuke Shimo; Takahiro Sogo; Azusa Hitomi; Hiroshi Ueda; Teruyuki Nagamune
JOURNAL OF BIOTECHNOLOGY, Jan. 2008, [Reviewed] - Mimicry of erythropoietin and interleukin-6 signalling by an antibody/cytokine receptor chimera in murine myeloid 32D cells
Masahiro Kawahara; Hiroshi Ueda; Kouhei Tsumoto; Izumi Kumagai; Teruyuki Nagamune
JOURNAL OF BIOCHEMISTRY, Apr. 2007, [Reviewed] - Antigen-mediated growth control of hybridoma cells via a human artificial chromosome.
Kawahara M; Inoue T; Ren X; Sogo T; Yamada H; Katoh M; Ueda H; Oshimura M; Nagamune T
Biochimica et biophysica acta, Feb. 2007, [Reviewed] - Antigen-mediated growth control of hybridoma cells via a human artificial chromosome
Masahiro Kawahara; Toshiaki Inoue; Xianying Ren; Takahiro Sogo; Hidetoshi Yamada; Motonobu Katoh; Hiroshi Ueda; Mitsuo Oshimura; Teruyuki Nagamune
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Feb. 2007, [Reviewed] - Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer
Masahiro Kawahara; Yuko Ogo; Kouhei Tsumoto; Izumi Kumagai; Hiroshi Ueda; Teruyuki Nagamune
CYTOTECHNOLOGY, Nov. 2006, [Reviewed] - Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome
H Yamada; A Kunisato; M Kawahara; CGT Tahimic; XY Ren; H Ueda; T Nagamune; M Katoh; T Inoue; M Nishikawa; M Oshimura
JOURNAL OF HUMAN GENETICS, Feb. 2006, [Reviewed] - An antigen-mediated selection system for mammalian cells that produce glycosylated single-chain Fv
P Pihkala; M Kawahara; H Ueda; T Nagamune
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2004, [Reviewed] - Antigen-mediated genetically modified cell amplification (AMEGA) with single vector transduction
E Kaneko; M Kawahara; K Tsumoto; Kumagai, I; H Ueda; T Nagamune
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, Oct. 2004, [Reviewed] - Improved growth response of anti body/receptor chimera attained by the engineering of transmembrane domain
M Kawahara; Y Ogo; H Ueda; T Nagamune
PROTEIN ENGINEERING DESIGN & SELECTION, Oct. 2004, [Reviewed] - Reversal of antigen-dependent signaling by two mutations in antibody/receptor chimera: implication of inverse agonism in cytokine receptor superfamily
M Kawahara; S Ishii; K Tsumoto; Kumagai, I; H Ueda; T Nagamune
BIOCHEMICAL PHARMACOLOGY, Aug. 2004, [Reviewed] - Selection of genetically modified cell population using hapten-specific antibody/receptor chimera
M Kawahara; H Kimura; H Ueda; T Nagamune
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2004, [Reviewed] - AMEGA: antigen-mediated genetically modified cell amplification
M Kawahara; H Ueda; K Tsumoto; Kumagai, I; T Nagamune
JOURNAL OF IMMUNOLOGICAL METHODS, Jan. 2004, [Reviewed] - Bypassing antibiotic selection: positive screening of genetically modified cells with an antigen-dependent proliferation switch.
Kawahara M; Ueda H; Morita S; Tsumoto K; Kumagai I; Nagamune T
Nucleic acids research, 2003, [Reviewed] - Cell proliferation switch responsive to fluorescein dimer
H Kimura; M Kawahara; IM Tomlinson; H Ueda; T Nagamune
ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 13, 2003, [Reviewed] - Selection of highly productive mammalian cells based on an inducible growth advantage using an antibody/receptor chimera
M Kawahara; H Ueda; K Tsumoto; Kumagai, I; W Mahoney; T Nagamune
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Apr. 2002, [Reviewed] - Antigen-mediated genetically modified cell amplification
Kawahara M; Ueda H; Tsumoto K; Kumagai I; Mahoney W; Nagamune T
ACS Symposium Series, 2002, [Reviewed] - Lysozymee-dependent proliferation switch: Hematopoietic and hybridoma cell growth control with the use of antibody/gp130 chimera
M Kawahara; A Natsume; S Terada; K Kato; K Tsumoto; Kumagai, I; M Miki; WC Mahoney; H Ueda; T Nagamune
ANIMAL CELL TECHNOLOGY : BASIC & APPLIED ASPECTS, VOL 12, 2002, [Reviewed] - Replacing factor-dependency with that for lysozyme: Affordable culture of IL-6-dependent hybridoma by transfecting artificial cell surface receptor
M Kawahara; A Natsume; S Terada; K Kato; K Tsumoto; Kumagai, I; M Miki; W Mahoney; H Ueda; T Nagamune
BIOTECHNOLOGY AND BIOENGINEERING, Sep. 2001, [Reviewed] - A growth signal with an artificially induced erythropoietin receptor-gp130 cytoplasmic domain heterodimer
M Kawahara; H Ueda; K Tsumoto; Kumagai, I; W Mahoney; T Nagamune
JOURNAL OF BIOCHEMISTRY, Aug. 2001, [Reviewed] - Cell-growth control by monomeric antigen: the cell surface expression of lysozyme-specific Ig V-domains fused to truncated Epo receptor
H Ueda; M Kawahara; T Aburatani; K Tsumoto; K Todokoro; E Suzuki; H Nishimura; PA Schueler; G Winter; WC Mahoney; Kumagai, I; T Nagamune
JOURNAL OF IMMUNOLOGICAL METHODS, Jul. 2000, [Reviewed]
MISC
- Economical and Efficient Production of Cardiac Myocytes From ES Cells and iPS Cells Using Small Molecule-Responsive Artificial Receptors For Wnt3a Signal Transduction
Takahiro Sogo; Asako Shigeno; Maruno Takaaki; Koji Hasegawa; Masahiro Kawahara; Hiroshi Ueda; Teruyuki Nagamune; Teruhisa Kawamura
CIRCULATION, Nov. 2011 - Cell-growth control by antibody/cytokine receptor chimera
2000
Award
- Mar. 2018
"Outstanding contribution to project planning and activities in Division of Biochemical Engineering"
The Society of Chemical Engineers, Japan, Division Coordination Team Prize
KAWAHARA Masahiro - Dec. 2016
Best Teaching Award in 2016, School of Engineering, The University of Tokyo
KAWAHARA Masahiro - Sep. 2016
「キメラ受容体による細胞運命制御系の構築とライブラリー選択への応用」
Encouragement Award of the Society for Biotechnology, Japan (Terui Award) - Feb. 2010
Biotechnology and Bioengineering Top 50 Reviewers in 2009 - Mar. 2009
「受容体の工学的改変による細胞機能の制御技術の開発」
The Society of Chemical Engineers, Japan, The SCEJ Award for Outstanding Young Researcher - Oct. 2008
Research grant from Japan Bioindustry Association (JBA), “Development of antibody selection system based on growth activity of mammalian cells” - Oct. 2002
The Naito Foundation, The 31st Naito Conference Award, “Selective expansion method of genetically modified stem cells”
Others
- Sep. 2023 - Sep. 2023
化学工学会第54回秋季大会 バイオ部会シンポジウム「蛋白質工学から生命化学工学への展開 ~上田宏先生の先駆的業績が残されたもの~」 オーガナイザー: 神谷 典穂(九州大学)・河原 正浩(医薬基盤・健康・栄養研究所), 福岡大学七隈キャンパス, 2023.9.12. - Mar. 2023 - Mar. 2023
化学工学会第88年会国際シンポジウム「Biomedical Engineering Challenges toward Intractable Diseases」オーガナイザー:河原正浩(医薬健栄研), 東京農工大学小金井キャンパス, 2023.3.16. - Sep. 2018 - Sep. 2018
第70回日本生物工学会大会シンポジウム「工学が見出すエッセンシャル細胞培養~動物細胞培養の根本に工学はどう立ち向かうか~」オーガナイザー:河原正浩(東京大学)・加藤竜司(名古屋大学)・児島 宏之(味の素),関西大学千里山キャンパス, 2018.9.7. - Jun. 2017 - Jun. 2017
第17回日本蛋白質科学会年会ワークショップ「Bottom-up design of functional artificial proteins in vitro and in vivo」オーガナイザー:新井亮一(信州大学)・河原正浩(東京大学), 仙台国際センター, 2017.6.20. - Sep. 2016 - Sep. 2016
第68回日本生物工学会大会シンポジウム 「遺伝子改変技術によるセルエンジニアリングの革新:産業応用に向けて」 オーガナイザー: 河邉佳典(九州大学)・河原正浩(東京大学), 富山国際会議場-ANA クラウンプラザホテル富山, 2016.9.28. - Sep. 2016 - Sep. 2016
第89回日本生化学会大会 フォーラム 「デザイナーペプチド・蛋白質が創成する新しい生化学」 オーガナイザー: 河原正浩(東京大学)・今中洋行(岡山大学), 仙台国際センター/東北大学川内北キャンパス, 2016.9.26. - Dec. 2015 - Dec. 2015
BMB2015(第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会)ワークショップ 「産業応用を指向した細胞の操作・計測技術の最先端」 オーガナイザー: 藤田聡史(産業技術総合研究所)・河原正浩(東京大学), 神戸ポートアイランド, 2015.12.4. - Jul. 2012 - Jul. 2012
日本生物工学会セルプロセッシング計測評価研究部会主催 「第4回 若手研究シンポジウム ~細胞の組織化と機能評価技術~」 オーガナイザー: 藤田聡史(産業技術総合研究所)・河原正浩(東京大学), モンタナリゾート岩沼, 2012.7.1. - Mar. 2012 - Mar. 2012
日本生物工学会セルプロセッシング計測評価研究部会主催 「第2回先端技術ワークショップ」 オーガナイザー: 宮本義孝(国立成育医療研究センター)・河原正浩(東京大学), 東京大学本郷キャンパス, 2012.3.15. - Sep. 2011 - Sep. 2011
日本生物工学会セルプロセッシング計測評価研究部会主催 「第1回先端技術ワークショップ」 オーガナイザー: 河原正浩(東京大学)他部会幹事一同, 東京大学本郷キャンパス, 2011.9.26. - Oct. 2010 - Oct. 2010
第62回日本生物工学会大会 「セルプロセッシング計測評価研究部会 優秀学生発表賞」 オーガナイザー: 井藤彰(九州大学)・河原正浩(東京大学), 宮崎シーガイア, 2010.10.28–29. - Sep. 2010 - Sep. 2010
化学工学会第42回秋季大会 「バイオ部会ポスターセッション」 オーガナイザー: 河原正浩(東京大学)、今中洋行(岡山大学)、安部道玄(東京工業大学), 同志社大学今出川キャンパス, 2010.9.6. - Nov. 2009 - Nov. 2009
日本生物工学会セルプロセッシング計測評価研究部会主催 「第1回 若手研究シンポジウム ~次世代を担う生物工学技術~」 オーガナイザー: 河原正浩(東京大学)・加藤竜司(名古屋大学), 神戸国際会議場, 2009.11.26.
Research Themes
- 31 May 2017 - 31 Mar. 2022
Integrated platform for mammalian cell-based cell and bioprocess engineering
Grant-in-Aid for Scientific Research (S), Osaka University - 01 Apr. 2018 - 31 Mar. 2021
Development of a platform technology for intracellular drug discovery
Grant-in-Aid for Scientific Research (B) - 30 Jun. 2017 - 31 Mar. 2019
Construction of a system to attain affinity maturation of anti-membrane protein antibodies
Grant-in-Aid for Challenging Research (Exploratory), The University of Tokyo - 01 Apr. 2016 - 31 Mar. 2018
Development of intrabody selection technology in mammalian cells
Grant-in-Aid for Challenging Exploratory Research, The University of Tokyo - 01 Apr. 2015 - 31 Mar. 2018
Development of a screening technique of protein-protein interaction inhibitors in the cytosolic environment
Grant-in-Aid for Scientific Research (B), The University of Tokyo - 01 Apr. 2015 - 31 Mar. 2018
Development and its applications of a versatile system for single cell array, imaging analysis and selective cell collection
Grant-in-Aid for Scientific Research (A), The University of Tokyo - 01 Apr. 2014 - 31 Mar. 2018
Fundamental research for genome-wide platform of industrial mammalian cells
Grant-in-Aid for Scientific Research (A) - 01 Apr. 2012 - 31 Mar. 2015
Development of technologies for maintaining undifferentiated state and inducing growth and differentiation of human iPS cell by using chimeric receptor
Grant-in-Aid for Scientific Research (B), The University of Tokyo
Courses
- 2025 - Present
Designer Cell Chemistry, Kogakuin University - 2025 - Present
Cell Biology, Kogakuin University - 2025 - Present
Introduction to Advanced Laboratory for Chemistry/Life Science, Kogakuin University - 2025 - Present
Basic Experiments in Chemistry and Life science, Kogakuin University - 2025 - Present
Experiments of Chemistry and Life Science III, Kogakuin University - 2025 - Present
Introduction to Chemistry and Life Science, Kogakuin University - 2021 - 2024
医薬基盤科学特別講義 - 2024 - Present
応用生物科学特論 - 2018 - 2019
Overview of Chemical Bioengineering - 2018 - 2019
Basic Biology - 2018 - 2019
バイオエンジニアリング輪講 - 2017 - 2019
化学生命工学最前線 - 2016 - 2019
生命科学 - 2011 - 2019
分子生物学III - 2002 - 2019
生命工学実験及演習 - 2019 - Present
分子生物化学I - 2019 - Present
プロテインエンジニアリング - 2010 - 2017
分子生物化学IV - 2017 - Present
化学生命工学基礎 - 2016 - Present
化学を使って生命や分子の謎を解く - 2011 - 2015
細胞工学特論第2 - 2011 - 2014
生命科学① - 2011 - 2013
本郷の研究室で最先端の化学・生命実験をしよう! - 2008 - 2010
バイオテクノロジーII - 2010 - Present
生命科学概論 - 2009 - Present
化学生命工学~未来への挑戦 - 2008 - Present
化学・生命系研究法 - 2003 - 2004
生命化学演習 - 2002 - Present
生命工学詳論
Member History
- Jun. 2023 - Present
Editorial Board Member, Seibutsu-kogaku Kaishi (Japanese journal published by The Society for Biotechnology, Japan) - Apr. 2018 - Present
Organizer Member, Development of Science Fields Based on Bio-analysis Forum, The Society for Biotechnology, Japan - Apr. 2018 - Present
Chief, Industrial Animal Cell Engineering for Next Generation (iACE) Forum, The Society for Biotechnology, Japan - Apr. 2018 - Present
Councillor, Japanese Association of Animal Cell Technology (JAACT) - Jun. 2015 - Present
Editorial Board Member, Sci. Rep. - Apr. 2008 - Present
Organizer Member, Division of Biochemical Engineering, The Society of Chemical Engineers, Japan - Apr. 2022 - Mar. 2024
Chief, Forum of Medical Bioengineering, Division of Biochemical Engineering, The Society of Chemical Engineers, Japan - Jun. 2015 - May 2019
Editorial Board Member, J. Biosci. Bioeng. - Apr. 2011 - Mar. 2018
Organizer-in-chief, Cell Processing Engineering Forum, The Society for Biotechnology, Japan - 2017 - 2017
Organizing Committee Member, The 69th Annual Meeting of the Society for Biotechnology, Japan - 2016 - 2016
Chairman, 2016 Summer Seminar of Young Researchers' Committee for Biotechnology - Apr. 2011 - Mar. 2013
Editorial Board Member, Chemical Engineering of Japan (Japanese journal published by The Society of Chemical Engineers, Japan) - Apr. 2010 - Mar. 2013
Editorial Board Member for “Topics” section, Bioscience and Industry (Japanese journal published by Japan Bioindustry Association) - 2012 - 2012
Organizing Committee Member, The 77th Annual Meeting for The Society of Chemical Engineers, Japan - Jan. 2011 - Dec. 2011
Editorial Board Member for “Biomedia” section, Seibutsu-kogaku Kaishi (Japanese journal published by The Society for Biotechnology, Japan) - Apr. 2009 - Mar. 2011
Organizer Member, Cell Processing Engineering Forum, The Society for Biotechnology, Japan - 2009 - 2009
Organizing Committee Member, Asia Pacific Biochemical Engineering Conference 2009 (APBioChEC’09) - 2008 - 2008
Organizing Committee Member, Young Asian Biochemical Engineer’s Community 2008 (YABEC2008) - 2004 - 2004
Organizing Committee Member,, Young Asian Biochemical Engineer’s Community 2004 (YABEC2004) - 2003 - 2003
Organizing Committee Member, The 68th Annual Meeting for The Society of Chemical Engineers, Japan